Symptoms & Diagnosis of hATTR Amyloidosis

Symptoms of hATTR amyloidosis involve multiple tissues and organs and can seem unrelated. Because symptoms may be confused with more common conditions, hATTR amylodiosis can be hard to identify.13

Patients often present with a cluster of one, two, three or more red-flag symptoms, including:1-12

References: 1. Gertz MA. Am J Manag Care. 2017;23(7 suppl):S107-S112; 2. Coelho T, et al. A physician’s guide to transthyretin amyloidosis. Research Gate Amyloidosis; Foundation, 2008. https://www.researchgate.net/publication/265490881_A_Physician’s_Guide_to _Transthyretin_Amyloidosis; 3. Nakagawa M et al. Amyloid 2016; 23(1): 58-63; 4. Cortese A et al. Journal of Neurology, Neurosurgery, and Psychiatry 2017; 88(5): 457-8; 5. Yanagisawa A et al. Modern Pathology 2015; 28(2): 201-7; 6. Donnelly JP, Hanna M. Cleve Clin J Med. 2017;84(12 suppl 3):12-26; 7. Ikram A, et al. J Card Fail. 2017;23(8):S11-S12(P021); 8. Galat A, et al. Eur Heart J. 2016;37(47):3525-31; 9. Adams D, Coelho T, Obici L, et al. Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study. Neurology. 2015;85(8):675-682; 10. Lousada I et al. Orphanet Journal of Rare Diseases 2017; 12(Suppl 1): 165 (P7); 11. Ando Y et al. Orphanet Journal of Rare Diseases 2013, 8:31; 2; 12. Conceição et al. Journal of the Peripheral Nervous System. 2016; 21:5-9 13. Ando Y et al. Orphanet Journal of Rare Diseases 2013;8:31.